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The Science of PerioVive

Hyaluronic acid (HA) is a naturally occurring, biocompatible molecule found throughout the extracellular matrix. In periodontal applications, HA acts as a regenerative bioscaffold — supporting organized healing, reducing irritation, and promoting the restoration of normal anatomy.

Control has gaps and tissue void along the periodontal ligament.

With HA, appropriate periodontal anatomy is restored.

At higher magnification, the periodontal ligament has interwoven collagen fibers and attachment to new bone and cementum

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Shirakata Y, Imafuji T,Nakamura T, et al. Periodontal wound healing/regeneration of two-wall intrabonydefects following reconstructive surgery with cross-linked hyaluronic acid-gelwith or without a collagen matrix: a preclinical study in dogs. QuintessenceInt.2021;52(4):308-316. doi:10.3290/j.qi.b937003

PHYSICAL
BARRIER

  • Protects the procedure site

  • Reduces tissue irritation

  • Limits microbial invasion

  • Shields exposed nerve endings from mechanical and chemical stimulation

MOLECULAR
SCAFFOLD

A “healing highway” that:

  • Supports keratinocyte migration

  • Encourages re-epithelialization

  • Promotes angiogenesis

  • Helps regulate inflammation

HYDROPHILIC
HYDRATION

  • Maintains a moist, anti-edematous environment

  • Supports re-epithelialization

  • Encourages healthier tissue architecture

Further Reading

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